6-Chloro-1H-pyrrolo[3,2-c]pyridine(CAS: 74976-31-1)

6-Chloro-1H-pyrrolo[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 192.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored away from moisture and heat.

6-Chloro-1H-pyrrolo[3,2-c]pyridine can be synthesized via chlorination of 1H-pyrrolo[3,2-c]pyridine. The reaction involves the use of thionyl chloride as a chlorinating agent. The reaction is carried out in an inert atmosphere to avoid side reactions, and the product can be purified by recrystallization or column chromatography.

6-Chloro-1H-pyrrolo[3,2-c]pyridine is used in the pharmaceutical industry for the synthesis of certain antipsychotic drugs. It is also used in the semiconductor industry as a dopant for organic semiconductors and in the polymer industry for the development of conductive polymers.

When handling 6-Chloro-1H-pyrrolo[3,2-c]pyridine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up carefully, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.