2-Phenyl-3-pyridinamine(CAS: 101601-80-3)

2-Phenyl-3-pyridinamine is a crystalline compound with a molecular weight of approximately 168.18 g/mol. It is slightly soluble in water and has a high solubility in organic solvents like ethanol and acetone. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It exhibits a melting point around 160-162°C.

2-Phenyl-3-pyridinamine is commonly synthesized via the condensation of 3-aminopyridine with phenyl isocyanate. The reaction typically proceeds with good yield (up to 85%) and selectivity, although the use of a catalyst like 4-dimethylaminopyridine (DMAP) can enhance the reaction efficiency.

2-Phenyl-3-pyridinamine finds applications in the pharmaceutical industry as a starting material for drug synthesis. It is also used in the polymer industry for the development of functionalized polymers. Additionally, it has potential uses in the production of sensors and semiconductors due to its unique electronic properties.

When handling 2-Phenyl-3-pyridinamine, it is crucial to ensure proper ventilation and use a fume hood. Wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Store the compound in a cool, dry place, away from oxidizers and flammable materials. In case of a spill, use appropriate absorbent materials and follow safety data sheet (SDS) guidelines for disposal.