2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid(CAS: 4394-00-7)

2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid (CAS: 4394-00-7) is a crystalline solid with a molecular weight of approximately 333.14 g/mol. It has a solubility of about 5.8 mg/mL in water and is slightly soluble in ethanol. This compound is known for its high reactivity, particularly towards nucleophilic substitution reactions.

2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid is typically synthesized via amidation of nicotinic acid with 3-(trifluoromethyl)aniline. The process often requires the use of a catalyst such as triethylamine and proceeds under mild conditions. The yield can be up to 85% with good selectivity.

2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid (CAS: 4394-00-7) is primarily used in the pharmaceutical industry as a precursor for drug development. It has applications in polymers and sensors due to its unique chemical properties, but its most notable use is in the synthesis of medicinal compounds.

When handling 2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid (CAS: 4394-00-7), it is essential to use proper personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of spill, follow the emergency procedures outlined in the safety data sheet (SDS) and dispose of materials according to local regulations.