3-Bromo-5-hydroxy-4-methoxybenzoic acid(CAS: 52783-66-1)

3-Bromo-5-hydroxy-4-methoxybenzoic acid is a white crystalline solid with a molecular weight of 264.03 g/mol. It has a solubility of 0.037 g/L in water at 20°C. The compound is relatively stable but can undergo hydrolysis under basic conditions. It is a weak acid with a pKa of about 3.4.

3-Bromo-5-hydroxy-4-methoxybenzoic acid can be synthesized via the bromination of 5-hydroxy-4-methoxybenzoic acid followed by protection of the hydroxyl group. Common methods include the use of N-bromosuccinimide (NBS) in an appropriate solvent such as acetone or dichloromethane. The yield depends on the purity of starting materials and reaction conditions.

3-Bromo-5-hydroxy-4-methoxybenzoic acid is used in the pharmaceutical industry for the synthesis of various pharmaceuticals due to its structural complexity. It also finds applications in the chemical industry for sensor development and as an intermediate in the production of other organic compounds.

When handling 3-Bromo-5-hydroxy-4-methoxybenzoic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of spills, use appropriate spill containment and clean up materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information.