1-Acetyl-5-(2-aminopropyl)-1H-indole-7-carbonitrile(CAS: 175837-01-1)

1-Acetyl-5-(2-aminopropyl)-1H-indole-7-carbonitrile is a solid compound with a crystalline form. Its molecular weight is approximately 304.26 g/mol. It has limited water solubility, with a solubility of about 0.2 g/L at 25°C. This compound is moderately reactive due to its functional groups, particularly the nitrile group, which can undergo hydrolysis under basic conditions. It is stable under normal laboratory conditions but should be stored away from moisture and strong acids.

1-Acetyl-5-(2-aminopropyl)-1H-indole-7-carbonitrile is synthesized through a multi-step process involving the reaction of indole with acetyl chloride followed by coupling with an amino propyl derivative. This synthesis typically requires anhydrous conditions and is catalyzed by a suitable reagent. The overall yield is moderate, around 50-70%, with high selectivity towards the desired product due to the specific reactivity of the indole ring.

1-Acetyl-5-(2-aminopropyl)-1H-indole-7-carbonitrile is primarily used in the pharmaceutical industry for the development of new drugs. It also shows potential in the polymer industry as a monomer or additive. Additionally, this compound can be used in the sensor and semiconductor industries due to its unique chemical properties, though its specific applications in these fields are still being explored.

When handling 1-Acetyl-5-(2-aminopropyl)-1H-indole-7-carbonitrile, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area, preferably a fume hood, to minimize exposure to the compound. Spills should be cleaned up immediately using appropriate spill kits, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.