1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone(CAS: 1190865-44-1)

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone is a crystalline solid with a molecular weight of approximately 336.02 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetone. The compound exhibits good reactivity towards nucleophiles and electrophiles, making it suitable for various synthetic applications.

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone is typically synthesized via a multistep process involving the protection of an alcohol functionality, followed by a fluorination reaction, and subsequent coupling reactions. The use of a palladium catalyst can enhance the selectivity and yield of the product.

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone is used in the pharmaceutical industry for the synthesis of intermediates and active pharmaceutical ingredients. It is also employed in the sensor industry for the development of chemical sensors, and in the semiconductor industry as a precursor for electronic materials.

When handling 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate containment measures, and the material safety data sheet (MSDS) should be consulted for detailed safety information.