Diethyl malonate(CAS: 105-53-3)

Diethyl malonate is a colorless liquid with the chemical formula C5H10O3. It is widely used in organic synthesis as a versatile building block, known for its reactivity in forming substituted malonic acid derivatives. Its molecular structure features a malonic ester group, making it essential in the synthesis of various pharmaceuticals and organic compounds.

Diethyl malonate is primarily used in the pharmaceutical industry to synthesize drugs, including antifungals and antihistamines. It also serves as a flavoring agent in food products and is employed in polymer production and research for creating complex organic molecules. Its applications span across chemical research, industrial manufacturing, and food science.

Diethyl malonate is classified as moderately toxic and requires careful handling. It should be used in well-ventilated areas with protective gloves, goggles, and lab coats. Safety standards such as GHS and OSHA emphasize avoiding skin and eye contact, while proper disposal is crucial. Always follow established protocols for its use and storage to ensure safety.

Diethyl malonate should be stored in a cool, dry place (0-25°C), away from light and moisture. Use tightly sealed, inert containers such as glass or polyethylene to maintain stability. Avoid exposure to high temperatures and incompatible materials. Store in a well-ventilated area to prevent vapor accumulation and ensure long-term safety.