3-bromo-5-(trifluoromethyl)pyridin-2-ol(CAS: 76041-73-1)

3-Bromo-5-(trifluoromethyl)pyridin-2-ol (CAS: 76041-73-1) is a crystalline compound with a molecular weight of approximately 253.04 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. The compound is known for its high reactivity, particularly in nucleophilic substitution reactions. Its physical properties include a melting point of around 140-142°C and a boiling point of approximately 320°C. It is a versatile intermediate in organic synthesis.

3-Bromo-5-(trifluoromethyl)pyridin-2-ol (CAS: 76041-73-1) is typically synthesized through a multi-step process involving bromination and fluorination reactions. A common method involves bromination of 5-(trifluoromethyl)pyridine followed by hydroxylation to form the desired compound. The synthesis can be carried out with the use of a Lewis acid catalyst, such as aluminum bromide, and requires careful control of reaction conditions to achieve high selectivity and yield. The process is often optimized using techniques such as column chromatography for purification.

3-Bromo-5-(trifluoromethyl)pyridin-2-ol (CAS: 76041-73-1) is used in various industries, including pharmaceuticals, where it serves as a key intermediate for the synthesis of complex molecules. It is also utilized in the production of polymers and sensors due to its unique chemical properties. In the semiconductor industry, it finds application as a chemical vapor deposition (CVD) precursor. Its versatility makes it a valuable compound in materials science and organic chemistry research.

When handling 3-bromo-5-(trifluoromethyl)pyridin-2-ol (CAS: 76041-73-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound is corrosive and can cause skin irritation or eye damage. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using personal protective equipment and follow the safety data sheet (SDS) guidelines for proper disposal. Always refer to the most recent SDS for detailed precautions and emergency response procedures.