(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate(CAS: 93635-76-8)

(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate is a colorless or white crystalline solid with a molecular weight of approximately 268.34 g/mol. It is moderately soluble in water and ethanol. This compound exhibits high reactivity due to the presence of hydroxyl and ester groups, making it susceptible to hydrolysis under basic conditions. It is slightly basic with a pKa around 7.5.

(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate can be synthesized via a multistep process involving the reaction of 2,2-dimethyl-1,3-dioxane-4-carbaldehyde with ethyl alcohol in the presence of sodium hydroxide. The yield is typically around 75%, and the reaction is highly selective for the desired stereochemistry.

(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate finds applications in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also used in the production of certain polymers and as a reagent in organic synthesis for its reactivity with hydroxyl and ester groups. Additionally, it can be employed in the development of sensors for detecting specific chemical compounds.

When handling (2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate (CAS: 93635-76-8), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate chemical spill kits, and the material safety data sheet (MSDS) should be consulted for detailed safety information. The compound is moderately reactive and should be stored in a cool, dry place, away from strong acids and bases.