N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide(CAS: 1191911-26-8)

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is a crystalline solid with a molecular weight of approximately 551.4 g/mol. It has a solubility of 1.3 g/L in water and is highly reactive towards nucleophiles. This compound shows good stability under neutral and slightly acidic conditions but may degrade under basic conditions.

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is typically synthesized through a multi-step process involving the coupling of 5-fluoropyrimidine with a morpholine derivative, followed by the introduction of the methoxyphenyl moiety and sulfonamidation. The reaction is catalyzed by a suitable organic base and proceeds with high selectivity and good yield.

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is primarily used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It may also find applications in the polymer industry for its functional groups, and in the development of sensors and semiconductors due to its chemical reactivity.

When handling N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the use of a fume hood to minimize exposure to the compound. Spills should be cleaned up using appropriate absorbents and following proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.