3-Fluoro-4-(trifluoromethoxy)phenol(CAS: 177596-38-2)

3-Fluoro-4-(trifluoromethoxy)phenol (CAS: 177596-38-2) is a crystalline solid with a molecular weight of approximately 264.07 g/mol. It has a low solubility in water but is more soluble in organic solvents. Chemically, it is relatively stable but can undergo substitution reactions. It has a strong absorption in the UV/Vis region due to the presence of a fluoro-substituted aromatic ring.

3-Fluoro-4-(trifluoromethoxy)phenol is typically synthesized through the chlorination of 4-(trifluoromethoxy)phenol followed by a substitution reaction with fluoroamine. Commonly used catalysts include bases like sodium hydride. The reaction yields a high purity product with good selectivity and yield.

3-Fluoro-4-(trifluoromethoxy)phenol (CAS: 177596-38-2) is primarily used in pharmaceuticals for the synthesis of active pharmaceutical ingredients (APIs). It is also utilized in the production of sensors and some specialty chemicals. Its applications in semiconductor manufacturing and polymer synthesis are less common but still relevant.

When handling 3-Fluoro-4-(trifluoromethoxy)phenol (CAS: 177596-38-2), always wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always check the Material Safety Data Sheet (MSDS) or SDS for detailed safety information.