4-Chloro-3,5-difluorobenzoic acid(CAS: 1160573-19-2)

4-Chloro-3,5-difluorobenzoic acid is a solid crystalline compound with a molecular weight of approximately 228.01 g/mol. It has a melting point of 180-182°C and is slightly soluble in water. Chemically, it is less reactive than other aromatic carboxylic acids but can undergo typical carboxylic acid reactions such as esterification, amide formation, and reduction. It is stable under normal storage conditions but should be protected from moisture.

4-Chloro-3,5-difluorobenzoic acid can be synthesized via the Friedel-Crafts alkylation of 3,5-difluorobenzoic acid with chlorine in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction yields a high purity product with good yield. Other methods include direct substitution of fluorinated benzene derivatives with chlorinating agents under appropriate conditions.

4-Chloro-3,5-difluorobenzoic acid is used in various industries, particularly in the pharmaceuticals and fine chemicals sector for the synthesis of intermediates and active pharmaceutical ingredients. It also finds application in the agrochemical industry, where it can be used in the development of herbicides and pesticides. Additionally, it is utilized in the production of polymers and sensors due to its chemical properties.

When handling 4-Chloro-3,5-difluorobenzoic acid, safety gloves and goggles should be worn. It is advisable to conduct reactions in a fume hood to minimize exposure to vapors. Proper ventilation is essential to prevent inhalation. Spills should be cleaned up carefully, and contaminated materials should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.