Compound Q&A

How is 4-Chloro-3,5-difluorobenzoic acid (CAS: 1160573-19-2) typically synthesized?

Answer

4-Chloro-3,5-difluorobenzoic acid
4-Chloro-3,5-difluorobenzoic acid can be synthesized via the Friedel-Crafts alkylation of 3,5-difluorobenzoic acid with chlorine in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction yields a high purity product with good yield. Other methods include direct substitution of fluorinated benzene derivatives with chlorinating agents under appropriate conditions.

About

English Name 4-Chloro-3,5-difluorobenzoic acid
Molecular Formula C7H3ClF2O2
Molecular Weight 192.548 g/mol
SMILES C1=C(C=C(C(=C1F)Cl)F)C(=O)O
InChIKey PVIHLHXXVCVGTP-UHFFFAOYSA-N
Last Updated: 2025-10-31 17:33

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