4-(Trifluoromethyl)benzoyl chloride(CAS: 329-15-7)

4-(Trifluoromethyl)benzoyl chloride (CAS: 329-15-7) is a colorless to pale yellow liquid with a molecular weight of 275.05 g/mol. It has a high boiling point (159-161°C) and low solubility in water (0.2 g/L). The compound is highly reactive, particularly towards nucleophiles, and is prone to hydrolysis under basic conditions. It crystallizes in the monoclinic system and is used in organic synthesis for its electrophilic aromatic character.

4-(Trifluoromethyl)benzoyl chloride (CAS: 329-15-7) can be synthesized by the reaction of 4-(trifluoromethyl)benzoic acid with thionyl chloride. The process involves heating the acid and thionyl chloride in a solvent like dichloromethane. This method provides good yields and control over the product. Catalysts such as aluminum chloride can be used to enhance reactivity and selectivity.

4-(Trifluoromethyl)benzoyl chloride (CAS: 329-15-7) is primarily used in the pharmaceutical and polymer industries for the synthesis of complex organic compounds. It serves as a key intermediate in the production of drugs, functional polymers, and materials with specific electronic properties. The compound is also utilized in the semiconductor industry for creating specialized coatings and in the production of sensors.

When handling 4-(Trifluoromethyl)benzoyl chloride (CAS: 329-15-7), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Use a fume hood to minimize exposure. Spills should be cleaned up carefully with absorbent materials and neutralized with a base. For detailed safety information, refer to the Safety Data Sheet (SDS). Storage should be in a cool, dry place, away from incompatible materials, and tightly sealed to prevent hydrolysis and evaporation.