Valsartan Methyl Ester(CAS: 137863-17-3)

Valsartan Methyl Ester (CAS: 137863-17-3) is a white to off-white crystalline powder with a molecular weight of approximately 332.42 g/mol. It has a solubility of about 2.6 mg/mL in water and is practically insoluble in most organic solvents. It is moderately reactive, undergoing hydrolysis under basic conditions. It is stable in acidic media.

Valsartan Methyl Ester is typically synthesized by the esterification of valsartan with methanol in the presence of an acid catalyst, such as sulfuric acid. The reaction is conducted under mild conditions to achieve a high yield of approximately 90%. The product is purified by recrystallization from ethanol.

Valsartan Methyl Ester (CAS: 137863-17-3) is primarily used in the pharmaceutical industry for its role as an intermediate in the synthesis of valsartan, a popular angiotensin II receptor antagonist used to treat hypertension and heart failure. It is also used in the research and development of other medicinal compounds.

When handling Valsartan Methyl Ester (CAS: 137863-17-3), it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of spills, use appropriate spill response materials and handle according to the Safety Data Sheet (SDS).