methyl 4-chloro-4-oxobutanoate(CAS: 1490-25-1)

Methyl 4-chloro-4-oxobutanoate (CAS: 1490-25-1) is a white crystalline solid with a molecular weight of approximately 160.54 g/mol. It is slightly soluble in water but readily soluble in organic solvents like ethanol and acetone. This compound exhibits good reactivity, particularly towards nucleophilic substitution and condensation reactions.

Methyl 4-chloro-4-oxobutanoate (CAS: 1490-25-1) is typically synthesized via the condensation of 4-chlorobutyraldehyde with methyl acetate in the presence of a Lewis acid catalyst, such as boron trifluoride. The reaction is carried out at room temperature, yielding a high selectivity and good yield.

Methyl 4-chloro-4-oxobutanoate (CAS: 1490-25-1) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the development of sensors and as a precursor in the production of some intermediates for the polymer industry.

When handling methyl 4-chloro-4-oxobutanoate (CAS: 1490-25-1), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be used in a well-ventilated area or a fume hood. Spills should be handled with care, and disposal should follow local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.