Ethyl 2-(2-iodophenyl)acetate(CAS: 90794-29-9)

Ethyl 2-(2-iodophenyl)acetate (CAS: 90794-29-9) is a white crystalline solid with a molecular weight of approximately 315.03 g/mol. It has a low solubility in water but is more soluble in common organic solvents like ethanol and acetone. Chemically, it is less reactive compared to other esters due to the electron-withdrawing iodine substituent, which decreases nucleophilic attack at the ester carbonyl. It displays good stability under normal conditions but may undergo hydrolysis in strongly basic conditions.

Ethyl 2-(2-iodophenyl)acetate (CAS: 90794-29-9) is typically synthesized via an iodination reaction of ethyl acetate with 2-phenylacetyl chloride in the presence of an iodide source and a base like triethylamine. The reaction is typically carried out in an inert solvent such as dichloromethane. Catalysts such as sodium iodide or potassium iodide are often used to promote the reaction, leading to a high yield of the desired product.

Ethyl 2-(2-iodophenyl)acetate (CAS: 90794-29-9) is used in the pharmaceutical industry for the synthesis of certain drugs due to its unique chemical structure. It is also utilized in the polymer industry as a monomer precursor and in the development of sensors and semiconductors for its ability to form stable and functional materials under various conditions.

When handling Ethyl 2-(2-iodophenyl)acetate (CAS: 90794-29-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. Use in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using absorbent materials, and the area should be thoroughly rinsed with water. Consult the Safety Data Sheet (SDS) for detailed handling and disposal information.