1-(3-Fluorophenyl)-1-propanone(CAS: 455-67-4)

1-(3-Fluorophenyl)-1-propanone (CAS: 455-67-4) is a colorless to light yellow liquid at room temperature. It has a molecular weight of approximately 154.14 g/mol and a boiling point of 156-158°C. Its solubility in water is low, approximately 0.5 g/100 mL. The compound is highly reactive, particularly towards nucleophiles and can undergo various organic reactions such as nucleophilic substitution and condensation reactions.

1-(3-Fluorophenyl)-1-propanone can be synthesized via the reaction of 3-fluorophenylmagnesium bromide with acetyl chloride in the presence of a base like potassium tert-butoxide. The reaction typically yields a high purity product with good selectivity and a yield of around 70-80%. Catalytic hydrogenation can also be used to generate the corresponding alcohol.

1-(3-Fluorophenyl)-1-propanone (CAS: 455-67-4) is primarily used in the pharmaceutical industry for the synthesis of intermediates and active pharmaceutical ingredients. It also finds applications in the production of certain polymers and as a precursor in the development of organic sensors and materials for semiconductors.

When handling 1-(3-Fluorophenyl)-1-propanone (CAS: 455-67-4), it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be immediately neutralized and cleaned up using appropriate chemicals. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage to ensure safe laboratory practices.