Compound Q&A
How is 1-(3-Fluorophenyl)-1-propanone (CAS: 455-67-4) typically synthesized?
Answer
1-(3-Fluorophenyl)-1-propanone can be synthesized via the reaction of 3-fluorophenylmagnesium bromide with acetyl chloride in the presence of a base like potassium tert-butoxide. The reaction typically yields a high purity product with good selectivity and a yield of around 70-80%. Catalytic hydrogenation can also be used to generate the corresponding alcohol.
About
CAS No
455-67-4
English Name
1-(3-Fluorophenyl)-1-propanone
Molecular Formula
C9H9FO
Molecular Weight
152.17 g/mol
SMILES
CCC(=O)C1=CC(=CC=C1)F
InChIKey
RPMOHVRRKYJFSB-UHFFFAOYSA-N
Last Updated: 2025-09-26 00:09
