6-Methyl-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)(CAS: 71472-57-6)

6-Methyl-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is a crystalline solid with a molecular weight of approximately 245.7 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is relatively stable but can undergo hydrolysis under basic conditions. It has a pKa of about 5.5, indicating it is a weak acid.

6-Methyl-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is typically synthesized by the condensation of methyl acrylate with hydrazine, followed by reaction with a base to form the hydrochloride salt. This process involves mild conditions and is carried out in a suitable solvent.

6-Methyl-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is used in the pharmaceutical industry for its potential as a drug intermediate. It also has applications in the polymer industry for modifying polymers and in the development of sensors for detecting specific chemical compounds.

When handling 6-Methyl-3,4-dihydro-2H-1,4-benzoxazine hydrochloride, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be neutralized with an appropriate base and cleaned up carefully. Always refer to the Safety Data Sheet (SDS) for detailed safety information.