4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid(CAS: 144690-04-0)

4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid is a white to off-white crystalline solid with a molecular weight of approximately 300.4 g/mol. It is slightly soluble in water and ethanol. The compound exhibits acidic properties due to the carboxylic acid group, making it reactive towards bases and nucleophiles.

4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid can be synthesized via a multi-step process involving condensation of 2-propylimidazole-5-carboxylic acid with 2-hydroxypropan-2-yl bromide. The reaction is typically performed under reflux conditions in an inert solvent like toluene, with the use of a catalyst such as sodium hydride to improve the yield.

4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid finds applications in the pharmaceutical industry as a potential drug candidate due to its structural characteristics. It is also utilized in the development of sensors and as a functional group in polymer chemistry for its reactivity and solubility properties.

When handling 4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a fume hood to avoid inhalation and ensure proper ventilation. Store the compound in a dry, cool place away from direct sunlight. In case of skin contact, wash with soap and water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.