N-{4-[(4S)-2,5-Dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide(CAS: 42267-27-6)

N-{4-[(4S)-2,5-Dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide is a white to off-white crystalline solid with a molecular weight of approximately 354.27 g/mol. It has low water solubility and is soluble in organic solvents like dimethylformamide (DMF), acetonitrile, and dichloromethane. The compound is known for its reactivity towards nucleophiles and its ability to form stable adducts with various functional groups. It is insoluble in water but soluble in polar solvents containing aprotic functional groups.

N-{4-[(4S)-2,5-Dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide can be synthesized via a multistep process involving the condensation of 4-(2,5-dioxo-1,3-oxazolidin-4-yl)butanoic acid with 2,2,2-trifluoroacetyl chloride. The reaction typically requires a suitable base such as triethylamine and is performed in anhydrous conditions to avoid side reactions. The yield can be optimized by using appropriate solvents and maintaining temperature and pH within optimal ranges.

N-{4-[(4S)-2,5-Dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds and drug intermediates. It is also utilized in the polymer industry for the development of special functional polymers. Additionally, it has applications in the sensor and semiconductor industries due to its unique chemical properties and reactivity.

When handling N-{4-[(4S)-2,5-Dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and protective clothing. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be promptly neutralized with an appropriate agent and cleaned up according to the Material Safety Data Sheet (MSDS/SDS). Handling should be performed with care to avoid skin contact and ingestion.