2,5-Difluoro-4-methylbenzonitrile(CAS: 1003708-66-4)

2,5-Difluoro-4-methylbenzonitrile (CAS: 1003708-66-4) is a colorless liquid with a low melting point of -31.7°C and a high boiling point of 246.2°C. Its molecular weight is approximately 171.12 g/mol. It has good solubility in organic solvents such as ethanol and acetone but is only slightly soluble in water. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions.

2,5-Difluoro-4-methylbenzonitrile (CAS: 1003708-66-4) is typically synthesized via the reaction of 2,5-difluoro-4-methylbenzoyl chloride with sodium cyanide in a polar aprotic solvent. The reaction provides a yield of about 85% to 90% with high selectivity. Commonly used solvents include dimethylformamide or acetonitrile, and the reaction is generally carried out under mild conditions.

2,5-Difluoro-4-methylbenzonitrile (CAS: 1003708-66-4) is used in various industries. It is particularly important in the pharmaceutical sector for the synthesis of certain drugs. Additionally, it finds applications in the polymer industry, where it can be used as a monomer. Other applications include its use in the production of sensors and as a precursor in semiconductor manufacturing.

Handling 2,5-Difluoro-4-methylbenzonitrile (CAS: 1003708-66-4) requires caution due to its chemical properties. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spillage, ensure the spill is handled in a fume hood, and immediate steps are taken to clean up using appropriate materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information.