1-Methyl-1H-pyrazole-5-carboxylic acid(CAS: 16034-46-1)

1-Methyl-1H-pyrazole-5-carboxylic acid is a white crystalline solid with a molecular weight of approximately 143.14 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol and ethanol. Chemically, it is a weak acid and can undergo esterification and amidation reactions. It is also prone to hydrolysis under basic conditions.

1-Methyl-1H-pyrazole-5-carboxylic acid can be synthesized via amidation of 1-methylpyrazole with an appropriate carboxylic acid chloride or anhydride. Commonly, triethylamine is used as a base, and the reaction is typically performed in anhydrous organic solvents. The yield is usually around 70-80%, and the purity can be enhanced through recrystallization.

1-Methyl-1H-pyrazole-5-carboxylic acid is used in pharmaceuticals for the synthesis of certain drugs, as a precursor in polymer synthesis for developing smart materials, and in the production of sensors for detecting specific analytes. It also finds applications in the semiconductor industry as a dopant.

When handling 1-Methyl-1H-pyrazole-5-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up using absorbent materials and the area should be flushed with water. Always refer to the safety data sheet (SDS) for detailed handling procedures and emergency response guidelines.