2,5-Difluoro-4-iodopyridine(CAS: 1017793-20-2)

2,5-Difluoro-4-iodopyridine is a crystalline solid with a molecular weight of approximately 265.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. The compound is known for its reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but can react with strong nucleophiles.

2,5-Difluoro-4-iodopyridine is typically synthesized via the reaction of 2,5-difluoropyridine with iodine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is carried out under anhydrous conditions to ensure high yield and selectivity. This method provides a good balance between reactivity and safety.

2,5-Difluoro-4-iodopyridine is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry for the development of special polymers with unique properties. It also finds applications in the sensor and semiconductor industries due to its reactive nature and stable electronic structure.

Proper personal protective equipment (PPE) is essential when handling 2,5-Difluoro-4-iodopyridine, including gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.