5-Fluoro-2-benzofuran-1,3-dione(CAS: 319-03-9)

5-Fluoro-2-benzofuran-1,3-dione is a crystalline solid with a molecular weight of approximately 219.07 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is known for its stability but can react with bases and certain organic reagents. It is used in various chemical transformations due to its reactivity with nucleophiles.

5-Fluoro-2-benzofuran-1,3-dione is typically synthesized via the oxidation of 5-fluoro-2-benzofuran using appropriate oxidizing agents like potassium permanganate or nitric acid. The reaction is carried out in aqueous media, and the yield is generally good, around 70-80%, with controlled selectivity to the desired product.

5-Fluoro-2-benzofuran-1,3-dione is used in the pharmaceutical industry for the synthesis of certain drugs due to its pharmacological properties. It is also utilized in the polymer industry for improving the properties of certain polymers. Additionally, it finds applications in the production of semiconductors and in the development of chemical sensors.

When handling 5-Fluoro-2-benzofuran-1,3-dione, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted within a fume hood to minimize exposure. Spills should be handled carefully using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed instructions. Storage should be in a cool, dry place away from direct sunlight and heat sources.