2-Nitroterephthalic acid(CAS: 610-29-7)

2-Nitroterephthalic acid is a white crystalline solid with a molecular weight of approximately 194.07 g/mol. It has a pKa of about 2.8 and is slightly soluble in water. The compound is highly reactive due to its aromatic nitro group and carboxylic acid functionality. It is used in various chemical reactions and applications due to its reactivity and stability under certain conditions.

2-Nitroterephthalic acid is commonly synthesized by nitration of terephthalic acid. The process involves the addition of nitric acid and sulfuric acid in the presence of a catalyst like aluminum trichloride. The reaction is typically conducted at low temperatures to control side reactions and improve selectivity. The yield can be up to 90% with proper conditions.

2-Nitroterephthalic acid finds applications in several industries. It is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for the production of polyesters, and in the semiconductor industry for the preparation of electronic materials. Additionally, it is utilized in the development of sensors and as a building block in organic synthesis.

Handling 2-Nitroterephthalic acid requires strict safety measures. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coats. Work in a fume hood to minimize exposure to fumes. Spills should be handled with caution using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and proper disposal methods.