7-Methoxy-1H-indole-3-carboxylic acid(CAS: 128717-77-1)

7-Methoxy-1H-indole-3-carboxylic acid is a white or off-white crystalline solid with a molecular weight of 217.22 g/mol. It has a slight pungent odor and is poorly soluble in water but soluble in organic solvents like methanol and ethanol. It is moderately reactive towards bases and can form salts. It does not react with acids under normal conditions.

7-Methoxy-1H-indole-3-carboxylic acid can be synthesized via the condensation of 7-methoxyindole with trichloroacetyl chloride in the presence of a catalyst like 4-Acetamidobenzene or 4-acetamidobenzoyl chloride. The reaction yields a mixture of isomers, with the desired product being separated by column chromatography.

7-Methoxy-1H-indole-3-carboxylic acid is used in the pharmaceutical industry as a precursor to synthesize various indole derivatives, which are important in drug development. It also finds applications in the synthesis of molecular sensors and as a component in certain semiconductor materials.

When handling 7-Methoxy-1H-indole-3-carboxylic acid, ensure use of personal protective equipment such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. Use a fume hood during manipulation to avoid inhalation of vapors. In case of a spill, clean up with appropriate absorbent material and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.