3-Formyl-4-methoxybenzoic acid(CAS: 91420-99-4)

3-Formyl-4-methoxybenzoic acid is a crystalline solid with a molecular weight of approximately 212.21 g/mol. It has a pKa of around 3.2 and is slightly soluble in water. This compound is reactive, particularly towards nucleophilic attack on the formyl group and the carboxylic acid functionality. It exhibits good solubility in organic solvents such as methanol and ethanol.

3-Formyl-4-methoxybenzoic acid can be synthesized by the oxidation of 4-methoxybenzyl alcohol using peroxyacids like peroxybenzoic acid. Alternatively, it can be prepared by formylation of 4-methoxybenzoic acid using formyl chloride and a base such as sodium hydride. The reaction typically provides high yields and good selectivity.

3-Formyl-4-methoxybenzoic acid finds applications in the pharmaceutical industry for the synthesis of various biologically active compounds. It is also used in the polymer industry as a monomer for the production of special polymers and in the semiconductor industry for its use in organic thin-film transistors and sensors.

When handling 3-Formyl-4-methoxybenzoic acid, proper personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. It should be stored in a cool, dry place, away from direct sunlight and heat sources. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.