Tert-butyl 4,4-difluoropiperidine-1-carboxylate(CAS: 281652-10-6)

Tert-butyl 4,4-difluoropiperidine-1-carboxylate (CAS: 281652-10-6) is a crystalline solid with a molecular weight of approximately 249.23 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dichloromethane. This compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions.

Tert-butyl 4,4-difluoropiperidine-1-carboxylate (CAS: 281652-10-6) is typically synthesized via the reaction of 4,4-difluoropiperazine with tert-butyl chloroformate in the presence of a base such as triethylamine. The process yields a high purity product with excellent regioselectivity and yield.

Tert-butyl 4,4-difluoropiperidine-1-carboxylate (CAS: 281652-10-6) is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for the modification of polymer properties and in the semiconductor industry for the development of functional materials.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be used when handling Tert-butyl 4,4-difluoropiperidine-1-carboxylate (CAS: 281652-10-6). It should be stored in a cool, dry place away from direct sunlight. Spills should be handled according to a Material Safety Data Sheet (MSDS) and appropriate containment measures should be taken to prevent environmental contamination. Fume hoods should be used during all handling and synthesis procedures.