5'-Deoxy-5-fluorocytidine(CAS: 66335-38-4)

5'-Deoxy-5-fluorocytidine is a crystalline compound with a molecular weight of approximately 272.93 g/mol. It has poor water solubility and higher solubility in organic solvents like DMSO. Chemically, it is highly reactive towards nucleophilic substitution and is resistant to hydrolysis. It decomposes at temperatures above 150°C.

5'-Deoxy-5-fluorocytidine is typically synthesized via a six-step process starting from cytosine. The key steps involve fluorination of cytosine to form 5-fluorocytosine, followed by coupling with 5'-deoxyribose. Commonly used catalysts include palladium(II) acetate for the coupling reaction, and the overall yield is around 70-80%.

5'-Deoxy-5-fluorocytidine is primarily used in the pharmaceutical industry for its antitumor properties. It is also explored in the polymer industry for its monomer potential, and in the semiconductor industry for its use in photoresists. Some applications include drug development and material science.

When handling 5'-Deoxy-5-fluorocytidine, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood. Store it in a cool, dry place away from direct sunlight. In case of spill, clean up with care and follow the Material Safety Data Sheet (MSDS) guidelines for disposal.