3-Bromo-5-(2-methyl-2-propanyl)-1-benzothiophene(CAS: 1780644-81-6)

3-Bromo-5-(2-methyl-2-propanyl)-1-benzothiophene is a white to pale yellow crystalline solid with a molecular weight of approximately 285.17 g/mol. It is slightly soluble in common organic solvents like dichloromethane and acetone. It is highly reactive towards nucleophiles, particularly bromine, and exhibits characteristic thiophene ring reactivity.

3-Bromo-5-(2-methyl-2-propanyl)-1-benzothiophene is typically synthesized via a bromination reaction of 5-(2-methyl-2-propanyl)-1-benzothiophene using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The yield is around 70-80% and the reaction is conducted under nitrogen atmosphere to avoid side reactions.

3-Bromo-5-(2-methyl-2-propanyl)-1-benzothiophene is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various medicinal compounds. It also finds applications in the semiconductor industry for doping purposes and in the development of chemical sensors.

When handling 3-Bromo-5-(2-methyl-2-propanyl)-1-benzothiophene, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent material and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed guidance.