(2S)-4-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid(CAS: 59768-74-0)

(2S)-4-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid is a white crystalline solid with a molecular weight of approximately 288.35 g/mol. It has a solubility of about 0.63 g/100 mL in water and is slightly soluble in ethanol. The compound is reactive towards strong bases but stable under acidic conditions. It is prone to hydrolysis in the presence of moisture and heat.

(2S)-4-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid is synthesized via the condensation of 2-methyl-2-propanol with 4-methoxy-4-oxobutanoic acid, followed by amidation using a suitable amine. Commonly, this reaction is catalyzed by a strong acid such as trifluoroacetic acid, with a yield of around 70-80%. The reaction is conducted in a solvent like dichloromethane or ethanol.

(2S)-4-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid finds applications in pharmaceuticals, particularly as a precursor to medicinal compounds. It is also utilized in polymer science for the synthesis of biodegradable polymers and in the development of advanced sensor materials. Additionally, it has potential uses in semiconductor technology, though its primary application is in the pharmaceutical sector.

Handling (2S)-4-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid requires caution due to its reactivity. Gloves, goggles, and a lab coat should always be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be neutralized with a suitable base and cleaned up promptly. Safety data sheets (SDS) should be consulted for additional information and emergency procedures. The compound is not flammable but may hydrolyze if exposed to moisture or heat, thus maintaining a dry environment is crucial.