3-(Benzyloxy)aniline(CAS: 1484-26-0)

3-(Benzyloxy)aniline (CAS: 1484-26-0) is a white crystalline solid with a molecular weight of approximately 216.24 g/mol. It has a pKa of about 9.2, indicating it is a weak base. The compound is poorly soluble in water (solubility < 0.01 g/L at 20°C) but more soluble in organic solvents like ethanol and acetone. It is moderately reactive towards nucleophiles and electrophiles, making it useful in organic synthesis.

3-(Benzyloxy)aniline is typically synthesized via the Feigl reaction, where an anilide is reduced and then alkylated with benzyl chloride. The reaction involves the use of hydrogenation catalysts like palladium on carbon and requires the addition of an acid scavenger. This method provides good yields and high selectivity for the desired product.

3-(Benzyloxy)aniline (CAS: 1484-26-0) finds applications in the pharmaceutical industry, where it serves as a precursor for the synthesis of certain drugs. It is also used in the production of dyes and pigments, and in the development of sensors and electronic materials. Its diverse applications make it a valuable intermediate in organic synthesis.

When handling 3-(Benzyloxy)aniline (CAS: 1484-26-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, protective goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and heat sources. Work in a well-ventilated area or fume hood to minimize inhalation. In case of a spill, immediately clean it up using appropriate absorbent materials, and consult the Safety Data Sheet (SDS) for detailed instructions. Always follow laboratory safety guidelines and handle chemicals with care.