N-(2,5-Dichlorobenzoyl)glycine(CAS: 667403-46-5)

N-(2,5-Dichlorobenzoyl)glycine is a white to off-white solid with a crystalline form. Its molecular weight is approximately 273.04 g/mol. The compound is slightly soluble in water and more soluble in organic solvents. It shows low reactivity in most conditions but can undergo hydrolysis under basic conditions. The compound is stable under normal storage conditions but should be protected from moisture and heat.

N-(2,5-Dichlorobenzoyl)glycine is typically synthesized through the coupling reaction of 2,5-dichlorobenzoyl chloride with glycine. This reaction is catalyzed by a Lewis acid such as aluminum chloride and proceeds under anhydrous conditions. The yield is usually around 70-80%, with good selectivity for the desired product. The reaction can be carried out in an appropriate solvent such as dichloromethane or acetonitrile.

N-(2,5-Dichlorobenzoyl)glycine is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the development of antifungal and antibiotic agents. It also finds applications in the production of certain polymers and sensors. Additionally, its unique structure makes it useful in the field of semiconductor materials for specific applications.

When handling N-(2,5-Dichlorobenzoyl)glycine, it is important to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. The compound should be stored in a cool, dry place, away from moisture and heat. In case of spill, it should be immediately cleaned up using appropriate safety measures. It is advisable to keep the safety data sheet (SDS) readily available for reference. The compound is not highly reactive but should still be handled with care to avoid potential irritation or inhalation.