Apremilast Impurity 67(CAS: 136285-65-9)

Apremilast Impurity 67 (CAS: 136285-65-9) is a white crystalline solid with a molecular weight of approximately 552.67 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and acetonitrile. The compound is known for its low reactivity under normal conditions but may undergo hydrolysis under acidic or basic conditions.

Apremilast Impurity 67 (CAS: 136285-65-9) is typically synthesized via a multi-step process involving nucleophilic substitution and condensation reactions. The synthesis generally uses catalysts like palladium acetate to enhance selectivity and yield, achieving a high purity product.

Apremilast Impurity 67 (CAS: 136285-65-9) is primarily used in the pharmaceutical industry, particularly in the development and quality control of apremilast, a drug used to treat plaque psoriasis and psoriatic arthritis. It may also have applications in academic research for studying the pharmacokinetics and pharmacodynamics of apremilast.

When handling Apremilast Impurity 67 (CAS: 136285-65-9), it is essential to use personal protective equipment (PPE) including gloves and safety goggles. Store the compound in a cool, dry place away from direct sunlight and heat sources. Always work in a well-ventilated area or under a fume hood. In case of spill, clean up with caution and refer to the Safety Data Sheet (SDS) for specific procedures.