SN-38(CAS: 86639-52-3)

SN-38 is a chemotherapy drug with the chemical name 7-ethyl-10-hydroxycamptothecin. It is a derivative of camptothecin, known for its ability to inhibit DNA topoisomerase I, which plays a key role in DNA replication. SN-38 is used in cancer treatment, particularly for colorectal cancer, and has a molecular formula of C21H20N2O6.

SN-38 is primarily used in oncology as an antineoplastic agent, especially in the treatment of metastatic colorectal cancer. It is also utilized in research for studying DNA damage and repair mechanisms. Due to its potent biological activity, it is a key component in the formulation of irinotecan, a widely prescribed chemotherapy drug.

SN-38 is a potent chemotherapy drug and must be handled with care. It can cause side effects such as gastrointestinal toxicity and myelosuppression. Safety protocols include proper personal protective equipment (PPE) and controlled storage. Its use is strictly regulated in medical and research settings to ensure safety and efficacy.

SN-38 should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is sensitive to light and moisture, so it must be kept in a sealed container. Proper storage conditions are essential to maintain its stability and potency, and it should be handled according to standard chemical safety guidelines.