3,5-Bis(2-methyl-2-propanyl)benzoic acid(CAS: 16225-26-6)

3,5-Bis(2-methyl-2-propanyl)benzoic acid is a solid with a crystalline form. It has a molecular weight of approximately 250.38 g/mol. Solubility in water is low, around 0.1 g/L. Chemically, it is relatively stable but can react with strong bases to form its salts. It is less reactive towards acids and is often used in synthetic organic reactions.

3,5-Bis(2-methyl-2-propanyl)benzoic acid is typically synthesized via the Friedel-Crafts alkylation of benzoic acid with 2-methyl-2-propanol. The reaction is catalyzed by aluminum chloride, and under these conditions, the stereochemistry at the 3 and 5 positions of the aromatic ring is controlled to yield the desired product with high selectivity.

3,5-Bis(2-methyl-2-propanyl)benzoic acid is used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also utilized in the polymer industry as a monomer and in the production of certain organic semiconductors. Additionally, it finds applications in the development of sensors and as a reagent in organic synthesis.

When handling 3,5-Bis(2-methyl-2-proanyl)benzoic acid, it is recommended to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate chemical clean-up kits. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.