Palm-glu(nhs)-otbu(CAS: 204521-63-1)

Palm-glu(nhs)-otbu is a semi-crystalline compound with a molecular weight of approximately 444.47 g/mol. It is poorly soluble in water but soluble in organic solvents such as DMF and DMSO. Chemically, it is a reactive ester that can undergo acylation reactions. It is stable under normal storage conditions but should be protected from moisture and heat.

Palm-glu(nhs)-otbu is synthesized by the esterification of palm-glu with N-hydroxysuccinimide (NHS) in the presence of a base like triethylamine. This reaction yields a mono-N-hydroxysuccinimidyl ester derivative of palm-glu, which is then coupled with tert-butyloxycarbonyl (t-Boc) to form the final product. The reaction is typically carried out under milder conditions to enhance selectivity and yield.

Palm-glu(nhs)-otbu is primarily used in the pharmaceutical industry for the formation of bioconjugates and in polymer chemistry for the introduction of functional groups. It is also relevant in the development of sensors and semiconductors due to its reactive nature and ability to form stable amide bonds.

Palm-glu(nhs)-otbu should be handled under fume hood conditions due to its potential for generating volatile fumes. Protective equipment such as gloves, goggles, and lab coats should be worn. Spills should be cleaned up using appropriate solvents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.