(2,4,6-Triisopropylphenyl)boronic acid(CAS: 154549-38-9)

(2,4,6-Triisopropylphenyl)boronic acid is a white to off-white crystalline solid with a molecular weight of approximately 358.43 g/mol. It is slightly soluble in water and ethanol. The compound is relatively stable but can react with strong acids and bases. It is used in various synthetic reactions due to its reactivity with organoboron reagents.

(2,4,6-Triisopropylphenyl)boronic acid is typically synthesized by the reaction of 2,4,6-triisopropylphenol with boron tribromide in the presence of a base such as potassium tert-butoxide. The reaction is carried out in an inert solvent like toluene to ensure high yield and selectivity.

(2,4,6-Triisopropylphenyl)boronic acid finds applications in pharmaceuticals, where it is used in the synthesis of certain drug intermediates. It is also utilized in the production of functionalized compounds for use in polymers and sensors. Additionally, it plays a role in the development of materials for semiconductors.

When handling (2,4,6-Triisopropylphenyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. The substance should be stored under nitrogen to prevent oxidation. In case of a spill, it should be handled in a fume hood, and proper safety data sheets (SDS) should be consulted for detailed guidance on spill cleanup and disposal.