2-(Bromomethyl)-1,3-benzoxazole(CAS: 73101-74-3)

2-(Bromomethyl)-1,3-benzoxazole is a white crystalline solid with a molecular weight of approximately 244.03 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive towards nucleophiles due to the presence of the bromomethyl group.

2-(Bromomethyl)-1,3-benzoxazole can be synthesized via a bromination reaction of 1,3-benzoxazole with bromine in the presence of a suitable solvent such as chloroform. The yield is typically around 70-80%, and the reaction mechanism involves electrophilic aromatic substitution followed by nucleophilic substitution at the methyl group.

2-(Bromomethyl)-1,3-benzoxazole is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry as a monomer in the development of new materials with specific properties. Additionally, it is utilized in sensor technology for its ability to respond to specific chemical stimuli.

When handling 2-(Bromomethyl)-1,3-benzoxazole, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be properly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.