Azido-PEG4-Amine(CAS: 951671-92-4)

Azido-PEG4-Amine (CAS: 951671-92-4) is a polyethylene glycol derivative with a molecular weight of approximately 450 Da. It is a white or off-white solid with a crystalline form. The compound has a high solubility in common organic solvents such as DMSO and DMF. It is reactive towards amine groups, enabling its use in conjugation reactions. The compound can be used in polymer synthesis and bioconjugation applications.

Azido-PEG4-Amine (CAS: 951671-92-4) is typically synthesized by condensation of azide and amine functionalities on a polyethylene glycol backbone. The reaction involves the coupling of a primary amine with an azide group under mild conditions, often in the presence of a coupling agent like EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) and HOBt (1-hydroxybenzotriazole). The yield is around 80-90% under optimal conditions.

Azido-PEG4-Amine (CAS: 951671-92-4) is widely used in the pharmaceutical industry for drug delivery systems and biomolecule conjugation. It is also utilized in polymer chemistry for the synthesis of functional polymers. The compound finds applications in the development of biosensors and semiconductor materials for electronic devices.

When handling Azido-PEG4-Amine (CAS: 951671-92-4), appropriate personal protective equipment (PPE) is essential, including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.