5-bromo-3-nitro-pyridin-2-amine(CAS: 6945-68-2)

5-Bromo-3-nitro-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 225.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. The compound is chemically reactive, especially towards nucleophiles and reducing agents, but stable under normal storage conditions.

5-Bromo-3-nitro-pyridin-2-amine can be synthesized via the nitration of 5-bromo-pyridine followed by reduction of the nitro group. Commonly used catalysts include sulfuric acid, and the reaction yields are typically around 70-85%. The process involves controlling temperature and reaction time to achieve high selectivity.

5-Bromo-3-nitro-pyridin-2-amine finds application in the pharmaceutical industry as an intermediate in drug synthesis. It is also utilized in the production of certain polymers and as a component in sensor technology. Additionally, it is used in the synthesis of semiconductors due to its electronic properties.

When handling 5-bromo-3-nitro-pyridin-2-amine, proper personal protective equipment (PPE) is essential, including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate absorbent materials and contaminated waste should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.