4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid(CAS: 75092-30-7)

4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS: 75092-30-7) is a crystalline solid with a molecular weight of approximately 279.04 g/mol. It has low solubility in water but is soluble in organic solvents like DMSO and methanol. The compound is moderately reactive, particularly with nucleophiles. It has a melting point of around 225°C and shows good stability under normal conditions.

4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid is typically synthesized via a multistep process involving the iodination of 1-methyl-1H-pyrazole-5-carboxylic acid. This can be achieved using iodine in the presence of a base like sodium hydride. The yield is generally around 70-80% with good selectivity. The reaction is performed under anhydrous conditions to prevent side reactions.

4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS: 75092-30-7) finds applications in the pharmaceutical industry for its potential use as a precursor in drug synthesis. It is also used in the chemical industry for developing new materials, particularly in the synthesis of dyes and pigments. Additionally, it has potential uses in analytical chemistry for developing sensors and in materials science for semiconductors and polymers.

When handling 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS: 75092-30-7), appropriate personal protective equipment (PPE) should be worn, including gloves and safety goggles. Store it in a cool, dry place away from incompatible materials. Use a fume hood during handling to minimize exposure. In case of a spill, dispose of the material according to local regulations and refer to the safety data sheet (SDS) for detailed instructions.