4-Phenylthieno[3,2-c]pyridine(CAS: 81820-65-7)

4-Phenylthieno[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 228.25 g/mol. It has low water solubility and moderate solubility in organic solvents such as ethanol and dimethylformamide. This compound exhibits good thermal stability and moderate reactivity towards nucleophiles. It is insoluble in water and miscible with common organic solvents.

4-Phenylthieno[3,2-c]pyridine is often synthesized through a multi-step process involving the reaction of a thieno[3,2-c]pyridine derivative with a phenyl Grignard reagent or similar nucleophile. The reaction is typically conducted in an anhydrous, inert atmosphere to prevent side reactions. The yield is generally around 70-80%, with a high degree of selectivity towards the desired product.

4-Phenylthieno[3,2-c]pyridine is used in the pharmaceutical industry for its potential in developing new drug candidates, particularly in the field of anticancer agents and as a scaffold for medicinal chemistry. It is also utilized in the semiconductor industry due to its electronic properties and in the polymer industry for its potential as a monomer or additive. Additionally, it plays a role in sensors due to its ability to interact with certain molecules and ions.

When handling 4-Phenylthieno[3,2-c]pyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and proper disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.