(4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide(CAS: 154127-42-1)

(4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide is a white to off-white crystalline solid with a molecular weight of approximately 469.58 g/mol. It is slightly soluble in water and highly soluble in organic solvents like ethanol and DMSO. This compound exhibits good stability under neutral to slightly acidic conditions but can hydrolyze under basic conditions. It is reactive towards nucleophiles and undergoes substitution reactions readily.

(4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide is synthesized through a multi-step process involving the reaction of 3-methoxypropyl chloride with 4-hydroxy-2-(thieno[3,2-e][1,2]thiazin-6-sulfonamido)butyric acid in the presence of a base such as triethylamine. The reaction is carried out in an organic solvent like dichloromethane. The yield is around 75%, and the product is purified by recrystallization.

(4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide is primarily used in the pharmaceutical industry for its potential anti-inflammatory and anticancer properties. It is also explored for its applications in the polymer industry for enhancing the mechanical properties of polymers and in the semiconductor industry as a dopant material.

When handling (4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.