Acetylsalicylic Acid EP Impurity B (Salicylic Acid USP Related Compound B) (CAS: 636-46-4)

Acetylsalicylic Acid EP Impurity B (CAS: 636-46-4) is a white crystalline solid with a molecular weight of approximately 138.12 g/mol. It is moderately soluble in water and ethanol. Chemically, it is less reactive than the main acetylsalicylic acid but still exhibits some acidity, similar to its parent compound, salicylic acid. This impurity is known for its low solubility in common organic solvents and its limited reactivity in typical chemical transformations.

Acetylsalicylic Acid EP Impurity B (CAS: 636-46-4) is typically synthesized through the acetylation of salicylic acid under controlled conditions. The process involves the reaction of salicylic acid with acetic anhydride in the presence of a catalyst, such as concentrated sulfuric acid, at a specific temperature. The yield varies depending on the purity of the starting materials and the reaction conditions.

Acetylsalicylic Acid EP Impurity B (CAS: 636-46-4) is primarily used in the pharmaceutical industry as a quality control and impurity reference material. It is also relevant in the analytical chemistry sector for the development and validation of analytical methods. Additionally, it may be used in research and development for studying the behavior of related compounds in various chemical processes.

When handling Acetylsalicylic Acid EP Impurity B (CAS: 636-46-4), it is important to use appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methods. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Proper storage in a cool, dry place away from direct sunlight is recommended.