2-Fluoro-4-methoxybenzonitrile(CAS: 94610-82-9)

2-Fluoro-4-methoxybenzonitrile is a colorless to pale yellow liquid with a molecular weight of approximately 183.07 g/mol. It has a melting point of 53-54°C and a boiling point of 176-178°C. The compound is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is reactive towards nucleophiles and can undergo substitution and addition reactions.

2-Fluoro-4-methoxybenzonitrile is typically synthesized via the reaction of 4-methoxybenzonitrile with hydrogen fluoride (HF) or trifluoroacetic acid (TFA) as a catalyst. The reaction yields the desired product with good selectivity. The yield is around 70-80%, and the process is carried out under mild conditions to avoid over-fluorination.

2-Fluoro-4-methoxybenzonitrile is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of organic semiconductors and as a precursor in the development of certain materials for sensors and electronic devices.

2-Fluoro-4-methoxybenzonitrile should be handled in a well-ventilated area or a fume hood. It is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Spills should be handled carefully by using absorbent materials, followed by proper disposal as hazardous waste. This material should be stored away from incompatible materials and in a cool, dry place. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.