Compound Q&A

How is 2-Fluoro-4-methoxybenzonitrile (CAS: 94610-82-9) typically synthesized?

Answer

2-Fluoro-4-methoxybenzonitrile
2-Fluoro-4-methoxybenzonitrile is typically synthesized via the reaction of 4-methoxybenzonitrile with hydrogen fluoride (HF) or trifluoroacetic acid (TFA) as a catalyst. The reaction yields the desired product with good selectivity. The yield is around 70-80%, and the process is carried out under mild conditions to avoid over-fluorination.

About

CAS No 94610-82-9
English Name 2-Fluoro-4-methoxybenzonitrile
Molecular Formula C8H6FNO
Molecular Weight 151.14 g/mol
SMILES COC1=CC(=C(C=C1)C#N)F
InChIKey HWKUZTFIZATJPM-UHFFFAOYSA-N
Last Updated: 2025-09-28 13:06

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