3-(4-Nitrophenyl)propanoic acid(CAS: 16642-79-8)

3-(4-Nitrophenyl)propanoic acid (CAS: 16642-79-8) is a white crystalline solid with a molecular weight of approximately 210.14 g/mol. It is sparingly soluble in water and has good solubility in organic solvents like ethanol and acetone. The compound is reactive towards bases and can undergo esterification and substitution reactions. It is often used in various chemical syntheses and pharmaceutical applications.

3-(4-Nitrophenyl)propanoic acid (CAS: 16642-79-8) is typically synthesized by reacting 4-nitrophenyl chloroformate with propanol in the presence of a base like triethylamine. The reaction yields the desired acid in good yield. The key steps include the formation of the nitrophenyl chloroformate followed by nucleophilic substitution with propanol, leading to the formation of the target compound.

3-(4-Nitrophenyl)propanoic acid (CAS: 16642-79-8) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the production of polymers and as a precursor in the development of sensors and semiconductors. Its use in these industries leverages its reactivity and specific chemical properties.

When handling 3-(4-Nitrophenyl)propanoic acid (CAS: 16642-79-8), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with care using appropriate cleanup materials, and the substance should be stored in a cool, dry place away from direct sunlight and sources of ignition. Safety data sheets (SDS) should be consulted for detailed handling and disposal information.